Effect of Slimming Teas on Lipid Profile and Antioxidant Status in High-Fat Diet-Induced Hyperlipidemic Female Albino Rats
DOI:
https://doi.org/10.71637/toxicologydigest.vol5no1.55Keywords:
Slimming tea, hyperlipidemia, lipid profile, antioxidant status, oxidative stress, rat model, high-fat dietAbstract
Background and Objective:
Herbal slimming teas are widely consumed in Nigeria for weight management, yet scientific data on their metabolic effects remain limited. This study evaluated the impact of two commercially available slimming teas on lipid profile and antioxidant status in high-fat diet-induced hyperlipidemic female albino rats.
Materials and Methods:
Forty-two female albino rats (250–300 g) were divided into seven groups (n=6). Hyperlipidemia was induced with a high-fat diet for 15 days. Rats then received daily oral treatments for 21 days: normal control, hyperlipidemic control, simvastatin, one of two slimming teas (Tea 1 or Tea 2) at 200 or 400 mg/kg. Serum lipid profile and antioxidant markers (GSH, GST, GPX, CAT, SOD, MDA) were measured. Data were analysed by one-way ANOVA followed by Tukey’s post-hoc test (p ≤ 0.05).
Results:
Hyperlipidemia induction was successfully confirmed. Administration of both slimming teas produced no statistically significant changes in serum TC, TG, HDL, LDL, or VLDL levels compared to the hyperlipidemic control (p ≤ 0.05). Antioxidant markers showed mostly non-significant effects, with modest elevations in GSH at lower doses but no consistent changes in MDA or other enzymes. Body weight gain was lower in high-dose tea groups.
Conclusion:
The tested slimming teas demonstrated limited effects on lipid profile and antioxidant status in this hyperlipidemic model. While trends toward modest modulation were observed, larger, longer-term studies are needed to fully establish efficacy and safety.
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