The Effects Of Coartem And Antioxidant Interactions On Selected Oxidative Stress Indicators, Liver Enzymes And Biomarkers Of oxicity In Albino Wistar Rats
DOI:
https://doi.org/10.71637/toxicologydigest.vol5no1.54Keywords:
Coartem, Toxicity, Antioxidant Interactions, Oxidative Stress, EffectAbstract
The effects of Coartem and antioxidant interactions on selected oxidative stress indicators, liver enzymes and biomarkers of toxicity in albino Wistar rats were studied. Fifty-five albino Wistar rats of mixed sexes were selected into eleven study groups of five rats per group. The effect of the various treatments on the weight of the rats, activities of serum enzymes (AST, ALT and ALP), concentrations of albumin and oxidative stress markers (GSH, MDA and SOD) were examined. Coartem treated group showed an increase (p<0.05) in the activities of AST, ALT and ALP in relation to control, there was also alterations in the liver architecture which are indicative of hepatotoxicity. Antioxidant groups administered concomitantly at the start of Coartem treatment showed a significant decrease (p<0.05) in the activities of serum ALP (for all antioxidant), AST (for Vitamin C and Garlic), ALT (for Garlic), SOD and MDA, a decrease in the activity of GSH. Antioxidant groups given mid-way Coartem treatment showed a decrease (p<0.05) in serum ALP (for Vitamin C), AST and ALT (for Vitamin E and Garlic), GSH and SOD (for all antioxidants), MDA (for Vitamin C). Moreover, for antioxidant groups given at the end of Coartem treatment, there were decrease (p<0.05) in the activities of serum ALP and AST (for Vitamin E and Garlic), ALT (for Vitamin E), GSH (for all antioxidants), MDA (for Vitamin E), but an increase in SOD activity (for Garlic). Histopathology of the liver tissues showed mild alterations in groups administered with antioxidants. Antioxidants given mid-way and towards the end of Coartem therapy had profound effect on reducing the oxidative stress imposes by Coartem, but the most effective treatment period was at the end. Of the three antioxidants used, Vitamin E and Garlic were more effective, but the most potent was Garlic.
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